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A simple and rapid high-pressure liquid chromatographic assay for pentobarbital and other barbiturates in serum
A Alila1, J E Heavner, P H Rosenberg
1Department of Anesthesiology, Helsinki University School of Medicine, Finland.
American Journal of Veterinary Research
|May 1, 1988
Abstract:
A single extraction technique for measuring pentobarbital and other barbiturates in serum involved high-pressure liquid chromatography and UV detection yielding a sensitivity for pentobarbital of about 1 microgram/ml. We concluded that the assay provides a practical method for use in pharmacokinetic studies and in serum concentration monitoring in experimental animals.