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Gastritis with valproate therapy.

W A Marks1, M P Morris, J B Bodensteiner

  • 1Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City.

Archives of Neurology
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

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Prolonged anticonvulsant therapy with valproic acid or divalproex sodium may lead to gastritis in children. Feeding difficulties like anorexia and vomiting are key symptoms, responding to H2-receptor antagonists or antacids.

Area of Science:

  • Pediatric Gastroenterology
  • Pharmacology
  • Clinical Medicine

Background:

  • Anticonvulsant medications, including valproic acid and divalproex sodium, are widely used in pediatric epilepsy management.
  • Gastrointestinal side effects are known complications of valproate therapy, particularly upon initiation.
  • The occurrence of gastritis following long-term anticonvulsant use in children is less commonly reported.

Observation:

  • Ten pediatric patients receiving prolonged anticonvulsant therapy with valproic acid or divalproex sodium were identified.
  • The primary presenting symptom was feeding difficulties, including anorexia and food refusal.
  • Vomiting occurred in two-thirds of patients; diarrhea, weight loss, and abdominal pain were less frequent.

Findings:

  • All ten children developed gastritis.

Related Experiment Videos

  • Occult blood in stool was a late-stage finding.
  • Gastritis symptoms resolved with H2-receptor antagonists and/or oral antacids, though prolonged treatment was often required to prevent relapse.

    • Implications:

    • Gastritis should be considered in children on long-term valproate therapy presenting with persistent or recurrent feeding difficulties.
    • Early recognition and treatment of valproate-induced gastritis can improve patient outcomes.
    • This study highlights a less common but significant adverse effect of long-term anticonvulsant use in pediatric populations.