Related Experiment Videos
[The complement system: a double edge sword in tumor progression]
Marie Daugan1, Remi Noe2, Wolf Herman Fridman3
1Inserm UMRS 1138, Centre de recherche des Cordeliers, équipe complément et maladies, 15, rue de l'École de Médecine, 75006 Paris, France - Sorbonne Paris Cité, Université Paris Descartes, Paris, France - Sorbonne Universités, UPMC Université Paris 06, Paris, France.
Abstract:
The complement system is a key component of the innate immunity, playing a role in pathogen elimination and in host homeostasis. The complement system has been considered for long time as an anti-tumoral element. However, recent studies showed a pro-tumoral effect of complement and particularly of the anaphylatoxines C3a and C5a in a large variety of tumor types. Complement proteins act on different levels of tumor progression, affecting the tumor cells, the angiogenesis and the immune microenvironment. The impact of the complement system on tumor progression seems to be cancer type-dependent and this has to be taken into account in the establishment of potential biomarkers and development of therapeutic strategies.