Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The complement system: a double edge sword in tumor progression].

Marie Daugan1, Remi Noe2, Wolf Herman Fridman3

  • 1Inserm UMRS 1138, Centre de recherche des Cordeliers, équipe complément et maladies, 15, rue de l'École de Médecine, 75006 Paris, France - Sorbonne Paris Cité, Université Paris Descartes, Paris, France - Sorbonne Universités, UPMC Université Paris 06, Paris, France.

Medecine Sciences : M/S
|October 11, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM.

Cell·2026
Same author

Fibroblasts hold the key to TLS formation.

Immunity·2026
Same author

Pan-cancer spatial atlas of tertiary lymphoid structures.

Science (New York, N.Y.)·2026
Same author

Tumour cell-intrinsic complement C1r and C1s regulate cancer cell fitness and shape the immune microenvironment in triple-negative breast cancer.

Cellular and molecular life sciences : CMLS·2026
Same author

Metachronous bilateral renal cancer with immune checkpoint blockade-mediated eradication of bone metastasis: case report.

Frontiers in oncology·2026
Same author

Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton.

Communications biology·2026
This summary is machine-generated.

The complement system, once thought to fight tumors, actually promotes cancer growth via anaphylatoxins C3a and C5a. Its role in cancer progression is complex and cancer-specific, impacting tumor cells, angiogenesis, and the immune microenvironment.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • The complement system is crucial for innate immunity and host defense.
  • Historically viewed as anti-tumoral, recent evidence suggests a pro-tumoral role for complement.
  • Anaphylatoxins C3a and C5a are implicated in promoting various tumor types.

Purpose of the Study:

  • To review the dual role of the complement system in cancer.
  • To elucidate the mechanisms by which complement influences tumor progression.
  • To highlight the cancer type-specific impact of complement.

Main Methods:

  • Literature review of recent studies on complement and cancer.
  • Analysis of complement's effects on tumor cells, angiogenesis, and the immune microenvironment.

Related Experiment Videos

  • Examination of cancer-type-specific complement activity.

    • Main Results:

    • Complement system, particularly C3a and C5a, demonstrates a pro-tumoral effect across diverse cancers.
    • Complement proteins influence tumor progression by affecting tumor cells, angiogenesis, and immune evasion.
    • The specific impact of complement varies significantly depending on the cancer type.

    Conclusions:

    • The complement system plays a complex, often pro-tumoral role in cancer progression.
    • Understanding cancer-specific complement activity is vital for developing targeted therapies.
    • Complement-based biomarkers and therapeutic strategies require careful consideration of cancer type.