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Related Experiment Videos

Biological evaluation of benzosuberones.

Haider Behbehani1, Kamal M Dawood1, Thoraya A Farghaly2,3

  • 1a Department of Chemistry, Faculty of Science , Kuwait University , Safat , Kuwait.

Expert Opinion on Therapeutic Patents
|October 11, 2017
PubMed
Summary

Benzosuberone derivatives show significant anti-tumor and anti-inflammatory properties. This review covers synthesis methods and diverse therapeutic applications of these potent compounds.

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Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Pharmacology

Background:

  • Benzosuberone derivatives are found in natural products with anti-tumor activity.
  • Synthetic benzosuberones exhibit diverse therapeutic effects, including anti-inflammatory and bacteriostatic properties.

Purpose of the Study:

  • To provide a comprehensive overview of benzosuberone synthesis methods.
  • To review the extensive biological activities and therapeutic potential of benzosuberone derivatives.

Main Methods:

  • Literature review of 130 references, including 32 patents up to Q1 2017.
  • Analysis of reported synthesis pathways and biological evaluations of benzosuberone scaffolds.

Main Results:

  • Benzosuberone scaffolds demonstrate broad biological applications, including anti-inflammatory, antimicrobial, and anti-tumor activities.
Keywords:
Benzosuberonesanti-inflammatoryantimicrobialantitumorbenzosuberanenzymes inhibitors

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  • Specific applications include inhibitors for selective estrogen receptor, anti-obesity, beta-amyloid production, HCV, Alzheimer's, and tuberculosis.

    • Conclusions:

    • Benzosuberone derivatives are highly biologically active, acting as potent anti-inflammatory, immunosuppressive, and anti-tumor agents.
    • These compounds show potential for treating sleep, eating, and reproductive disorders, and as vascular disrupting agents for cancer therapy.