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Updated: Feb 21, 2026

A Novel Method: Super-selective Adrenal Venous Sampling

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

A Novel Method: Super-selective Adrenal Venous Sampling.

Kohzoh Makita¹, Koshiro Nishimoto², Kanako Kiriyama-Kitamoto³

¹Department of Radiology, Nerima Hikarigaoka Hospital.

Journal of Visualized Experiments : Jove

|October 11, 2017

Summary

This summary is machine-generated.

A new super-selective adrenal venous sampling (ssAVS) method precisely locates hormone overproduction in adrenal glands. This technique aids in treating primary aldosteronism (PA) and subclinical Cushing's syndrome (SCS) when conventional methods fail.

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Last Updated: Feb 21, 2026

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Published on: September 15, 2017

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Published on: December 9, 2022

Area of Science:

Endocrinology
Interventional Radiology
Surgical Oncology

Background:

Primary aldosteronism (PA) and subclinical Cushing's syndrome (SCS) involve autonomous adrenal hormone overproduction.
Conventional adrenal venous sampling (cAVS) uses central vein samples and plasma cortisol concentrations (PCCs) for normalization.
cAVS has limitations in precisely identifying the location of hormone-producing lesions.

Purpose of the Study:

To introduce and describe a novel super-selective adrenal venous sampling (ssAVS) technique.
To evaluate the efficacy of ssAVS in diagnosing conditions like PA and SCS.
To present ssAVS findings in clinical cases.

Main Methods:

Development of a super-selective adrenal venous sampling (ssAVS) method using micro-catheters.
Collection of blood samples from adrenal tributary veins (TVs).
Application of ssAVS in three primary aldosteronism (PA) cases.

Main Results:

ssAVS allows for segmental lesion detection within adrenal glands.
Plasma aldosterone concentrations (PACs) in ssAVS samples do not require PCC normalization.
ssAVS successfully identified various PA and potential SCS-related lesions in the presented cases.

Conclusions:

The ssAVS method enables precise localization of adrenal hormone overproduction.
ssAVS facilitates targeted treatment, potentially sparing healthy adrenal tissue.
ssAVS is a valuable tool for managing PA, especially when cAVS is insufficient.