Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in number of somatostatin receptors in rat brain after adrenalectomy: normalization after glucocorticoid

M N Rodriguez1, A Gomez-Pan, E Arilla

  • 1Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Alcala de Henares, Madrid, Spain.

Endocrinology
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The expression of nNOS, iNOS and nitrotyrosine is increased in the rat cerebral cortex in experimental hepatic encephalopathy.

Neuropathology and applied neurobiology·2006
Same author

[Hungry bone syndrome related to hyperthyroidism].

Anales de medicina interna (Madrid, Spain : 1984)·2006
Same author

[The use of suprarenal scintigraphy in the differential diagnosis of suprarenal incidentaloma].

Revista clinica espanola·2005
Same author

Prescription patterns of recently graduated physicians in Colombia: a survey during the mandatory social work period.

Pharmacoepidemiology and drug safety·2004
Same author

Smoking in Colombian medical schools: the hidden curriculum.

Preventive medicine·2001
Same author

Growth hormone responses to oral glucose and intravenous thyrotropin-releasing hormone in acromegalic patients treated by slow-release lanreotide.

Journal of endocrinological investigation·2001
Same journal

Zingerone ameliorates ovarian impairment by regulating steroidogenesis and apoptosis in letrozole-treated mouse.

Endocrinology·2026
Same journal

Loss of the calorie restriction response protein DEPP1 worsens diet-induced obesity.

Endocrinology·2026
Same journal

Long noncoding RNAs mediate endocrine signaling and resistance in prostate cancer.

Endocrinology·2026
Same journal

Repeated Chemogenetic Activation of C1 Catecholamine Neurons Reduces Subsequent Glucoprivic Responses and Mimics HAAF.

Endocrinology·2026
Same journal

Postnatal exposure to maternal hypothyroidism leads to developmental delay and metabolic dysregulations in male mice.

Endocrinology·2026
Same journal

Discovery proteomics identification of factors contributing to gonadotropin β expression.

Endocrinology·2026
See all related articles

Adrenalectomy reduced somatostatin (SS) receptors in specific brain regions, but not SS concentration. Glucocorticoid replacement reversed these effects, suggesting a link between corticosteroids and SS in the brain.

Area of Science:

  • Neuroendocrinology
  • Neuropharmacology

Background:

  • Somatostatin (SS) is a neuropeptide with diverse functions in the central nervous system.
  • The influence of adrenal hormones on brain SS systems is not fully understood.

Purpose of the Study:

  • To investigate the impact of adrenalectomy on somatostatin receptor binding and concentration in distinct brain regions.
  • To determine the role of corticosteroids in modulating these somatostatin parameters.

Main Methods:

  • Adrenalectomy was performed in rats.
  • Concentration of SS-like immunoreactivity was measured.
  • Specific binding of [125I-Tyr11]SS to receptors was assessed in membrane preparations from cerebral cortex, hippocampus, striatum, and hypothalamus.
  • Effects of dexamethasone (glucocorticoid replacement) were evaluated.

Related Experiment Videos

Main Results:

  • Adrenalectomy did not alter SS concentration in any brain area studied.
  • A significant decrease in SS receptor number was observed in the hippocampus, striatum, and hypothalamus, but not the cerebral cortex.
  • No changes in SS receptor binding affinity were detected post-adrenalectomy.
  • Dexamethasone treatment fully reversed the decrease in SS receptors caused by adrenalectomy.

Conclusions:

  • Adrenalectomy modulates somatostatin receptor density in specific brain regions, indicating a role for adrenal hormones.
  • Corticosteroids appear to regulate SS receptor levels in the brain.
  • These findings suggest a potential interaction between the corticosteroid and somatostatin systems in regulating neuronal activity.