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Effects of somatostatin on self-stimulation behaviour in rats pretreated with a receptor blocker
M Balázs1, H Schwarzberg, G Telegdy
1Department of Pathophysiology, University Medical School, Szeged, Hungary.
European Journal of Pharmacology
|April 27, 1988
Abstract:
The effects of somatostatin on lateral hypothalamic self-stimulation were investigated in rats pretreated with haloperidol, bicuculline, phenoxybenzamine or propranolol. Somatostatin decreased the rate of self-stimulation. Halperidol, bicuculline and phenoxybenzamine potentiated the somatostatin-induced depression of self-stimulation behaviour. Propranolol had no effect. It is suggested that dopaminergic, GABAergic and noradrenergic systems are involved in the somatostatin-induced depression of self-stimulation.