Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth hormone and its modulation.

C Dieguez1, M D Page, J R Peters

  • 1Department of Medicine, University of Wales College of Medicine, Cardiff.

Journal of the Royal College of Physicians of London
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging.

Journal of endocrinological investigation·2024
Same author

AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction.

Metabolism: clinical and experimental·2020
Same author

Trabecular and cortical bone involvement in rheumatoid arthritis by DXA and DXA-based 3D modelling.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Role of leptin and ghrelin in the regulation of gonadal function.

Expert review of endocrinology & metabolism·2019
Same author

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression.

Nature communications·2018
Same author

Cooperative role of the glucagon-like peptide-1 receptor and β3-adrenergic-mediated signalling on fat mass reduction through the downregulation of PKA/AKT/AMPK signalling in the adipose tissue and muscle of rats.

Acta physiologica (Oxford, England)·2017
Same journal

A Change of Government and Its Effect on the NHS Hospital Outpatient Service.

Journal of the Royal College of Physicians of London·2019
Same journal

Erratum: Model for the Organisation of a Community-Based Rehabilitation Service.

Journal of the Royal College of Physicians of London·2019
Same journal

Telemedicine and beyond.

Journal of the Royal College of Physicians of London·2019
Same journal

Palliative Care in General Medicine.

Journal of the Royal College of Physicians of London·2019
Same journal

Medical Negligence.

Journal of the Royal College of Physicians of London·2019
Same journal

In Response.

Journal of the Royal College of Physicians of London·2019
See all related articles

Understanding growth hormone (GH) regulation is crucial for treating various conditions. Research highlights clinical applications of neuroregulation in acromegaly, diabetes, and short stature, with potential roles in other diseases.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Mechanisms regulating somatotroph cell growth and oncogene activation are not fully understood.
  • Significant clinical advancements have emerged from improved understanding of growth hormone (GH) neuroregulation.

Purpose of the Study:

  • To review the clinical implications of GH neuroregulation.
  • To explore the potential roles of GH in various disease states.

Main Methods:

  • Review of current literature on GH regulation and clinical applications.
  • Discussion of therapeutic strategies involving somatostatin (SS) analogues, GHRH, and cholinergic muscarinic receptor blockade.

Main Results:

  • Long-acting SS analogues are effective in treating acromegaly and offer symptomatic relief for vipomas and glucagonomas.

Related Experiment Videos

  • GHRH may treat short stature due to deficiency, but requires further study compared to recombinant human GH.
  • Inhibiting GH release, potentially with cholinergic blockade, may prevent diabetes complications.

    • Conclusions:

    • GH neuroregulation has significant clinical applications in endocrinology.
    • Further research is needed to confirm GHRH efficacy and explore GH's broader role in disease.
    • Targeting GH pathways offers therapeutic potential for diverse medical conditions.