Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Suncus murinus as a new experimental model for motion sickness.

S Ueno1, N Matsuki, H Saito

  • 1Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.

Life Sciences
|January 1, 1988
PubMed
Summary

The house musk shrew (Suncus murinus) shows sensitivity to motion sickness, making it a viable animal model. Certain antiemetic drugs effectively prevent motion sickness symptoms in this new model.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased superoxide dismutase activity in erythrocyte in Parkinson's disease.

The Japanese journal of psychiatry and neurology·1992
Same author

[Application of ultrasonography in chest diseases--usefulness of ultrasonography and physiologic evaluation of low pressure vascular system].

Nihon Kyobu Shikkan Gakkai zasshi·1992
Same author

Recent advances in the study of hepatocellular carcinoma.

The Keio journal of medicine·1992
Same author

Evaluation of cor pulmonale on a modified short-axis section of the heart by magnetic resonance imaging.

The American review of respiratory disease·1992
Same author

Impaired secretion of the elongated mutant of protein C (protein C-Nagoya). Molecular and cellular basis for hereditary protein C deficiency.

The Journal of clinical investigation·1992
Same author

A 50-year-old man with ulcerative colitis and severe anemia.

The Keio journal of medicine·1992

Area of Science:

  • Pharmacology
  • Neuroscience
  • Animal Models

Background:

  • Motion sickness is a common condition affecting humans.
  • Identifying reliable animal models is crucial for studying motion sickness and testing prophylactic drugs.

Purpose of the Study:

  • To evaluate the Suncus murinus (house musk shrew) as a potential experimental model for motion sickness.
  • To investigate the efficacy of various prophylactic drugs against motion sickness-induced vomiting in this model.

Main Methods:

  • Inducing motion sickness in Suncus murinus using mild reciprocal shaking (10-40 mm amplitude, 0.5-3.0 Hz frequency).
  • Administering various antiemetic drugs (scopolamine, chlorpromazine, promethazine, diphenhydramine, chlorphenylamine, methamphetamine, pyrilamine, meclizine, dimenhydrinate) via subcutaneous injection.

Related Experiment Videos

  • Observing adaptation to repeated motion stimuli over time.

    • Main Results:

    • Mild shaking reliably induced vomiting in Suncus murinus within 2 minutes.
    • Repetitive motion training led to adaptation, decreasing vomiting episodes and increasing latency.
    • Scopolamine, chlorpromazine, promethazine, diphenhydramine, chlorphenylamine, and methamphetamine demonstrated prophylactic effects against motion sickness.
    • Pyrilamine, meclizine, and dimenhydrinate showed weak or no effectiveness.

    Conclusions:

    • Suncus murinus is a sensitive and suitable animal model for studying motion sickness.
    • The study identified specific antiemetic drugs effective in preventing motion sickness in this new model.
    • This research provides a foundation for further investigation into motion sickness mechanisms and treatments using Suncus murinus.