Related Experiment Videos
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists
T Honoré1, S N Davies, J Drejer
1Ferroson Research Division, Soeborg, Denmark.
Science (New York, N.Y.)
|August 5, 1988
Abstract:
The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.