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[Circadian rhythm in myocardial infarct]
1Servicio de Cardiología, Hospital de Especialidades, Centro Médico La Raza, Instituto Mexicano del Seguro Social.
Insights
Myocardial Infarction (MI) onset follows a circadian rhythm, peaking between 8-9 a.m. This pattern is consistent across sexes but absent in younger patients or those on beta-blockers within 24 hours.
Area of Science:
- Cardiology
- Chronobiology
- Internal Medicine
Background:
- Myocardial Infarction (MI) is a leading cause of mortality.
- Understanding temporal patterns of MI onset may inform preventative strategies.
- Previous research suggests potential daily variations in cardiovascular events.
Purpose of the Study:
- To investigate whether the onset of Myocardial Infarction (MI) exhibits a circadian rhythm.
- To identify peak and trough times for MI occurrence.
- To explore potential influencing factors such as sex and age.
Main Methods:
- Analysis of clinical charts from 819 patients admitted to a Coronary Care Unit.
- Statistical evaluation to determine the significance of temporal patterns.
- Subgroup analysis based on sex, age, and medication use.
Main Results:
- A statistically significant circadian rhythm in MI onset was observed (p > 0.01).
- Maximal MI frequency occurred between 8-9 a.m., with minimal frequency at midnight.
- The observed circadian rhythm was independent of sex.
- No circadian rhythm was detected in patients younger than 45 years or those on beta-blockers within 24 hours prior to MI.
Conclusions:
- Myocardial Infarction (MI) onset is not random and follows a distinct circadian rhythm.
- The morning hours (8-9 a.m.) represent a high-risk period for MI.
- Specific patient groups, including younger individuals and those on beta-blockers, may not adhere to this typical circadian pattern.
Abstract:
In order to determine if the beginning of the Myocardial Infarction (MI) is at random along the day or if it follows a circadian rhythm, we analyzed the clinical charts of 819 patients admitted to the Coronary Care Unite. Among them, 645 were male and 174 female. It was established that the beginning of the MI follows a circadian rhythm with maximal frequency between 8 and 9 a.m. and minimal at 0 hours (p greater than 0.01). This rhythm is sex independent. In patients younger than 45 years as well as those who received beta-block agents in less than 24 hours previous the MI no circadian rhythm was observed.