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[Long-term beta adrenergic antagonists in spastic bronchopathies]
B Blaive1, F Nahon, F Lemoigne
1Service de Pneumologie-Allergologie, Hôpital Pasteur-Nice.
Allergie Et Immunologie
|April 1, 1988
Summary
Cardio-selective beta-blockers demonstrate good long-term tolerance in stable chronic obstructive bronchopathy patients. These medications effectively manage bronchodilator side effects like trembling and tachycardia.
Area of Science:
- Cardiology
- Pulmonology
- Pharmacology
Background:
- Beta-blockers are typically contraindicated in chronic obstructive bronchopathy.
- Concerns exist regarding their long-term tolerance and management of bronchodilator side effects.
Purpose of the Study:
- To assess the long-term tolerance of cardio-selective beta-blockers in stable chronic obstructive bronchopathy.
- To evaluate their efficacy in controlling bronchodilator-induced side effects such as trembling and tachycardia.
Main Methods:
- A 4-month cross-over, double-blind study.
- Involved 21 patients (8 asthmatics, 13 spastic bronchitics).
- Patients were treated with betaxolol and atenolol for 2 months each.
Main Results:
- Respiratory tolerance to beta-blockers was good throughout the study.
- Side effects associated with bronchodilator use were effectively controlled.
Conclusions:
- Cardio-selective beta-blockers are well-tolerated long-term in stable chronic obstructive bronchopathy.
- These agents can successfully mitigate adverse effects of concurrent bronchodilator therapy.