[Physiological role of pancreatic D-cells (mathematical study)]

The physiological role of pancreatic D cells has been studied by the method of mathematical simulation. D cells were proved to produce a sparing effect both on B and A cells, bringing about a more economical secretory response to these cells. The suppression of insulin secretion by pancreatic somatostatin is substantial at lower glucose concentration and is insignificant at higher glucose concentration. Vice versa, the effect of D cells on glucagon secretion is especially considerable at higher glucose concentration, being slight at lower glucose concentration. The presence of D cells is absolutely necessary for the Langerhans islets to function as an organ regulating the deposition and mobilization of the biological fuel.