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Bradykinin analogues: differential agonist and antagonist activities suggesting multiple receptors
K M Braas1, D C Manning, D C Perry
1Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
British Journal of Pharmacology
|May 1, 1988
Abstract:
Bradykinin analogues with specific antagonist activity in several bioassays were evaluated for effects on [3H]-bradykinin receptor binding sites and inositol phosphate production in neuroblastoma N1E-115 cells. The analogues varied in their affinities for bradykinin receptors in guinea-pig ileum and N1E-115 cell membranes, in their effects on uterine and ileal contractions and in their agonist or antagonist activity on phosphoinositide turnover in N1E-115 cells. These tissue specific effects suggest the presence of multiple bradykinin receptor subtypes.