Related Experiment Video

Updated: Aug 14, 2026

Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles
11:16

Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles

Published on: August 7, 2016

Somatostatin receptors in normal and tumoral tissue

J C Reubi1, S W Lamberts, R Maurer

  • 1Sandoz Research Institute, Berne, Switzerland.

Hormone Research
|January 1, 1988
PubMed

Insights

Somatostatin receptors are present in various tissues and certain tumors, including pituitary adenomas and meningiomas. Their detection suggests potential therapeutic targets for these somatostatin receptor-positive cancers.

Area of Science:

  • Endocrinology
  • Neuroscience
  • Oncology

Background:

  • Somatostatin receptors mediate somatostatin actions in target tissues like the brain and pituitary.
  • These receptors are also found in tumors derived from these tissues.

Purpose of the Study:

  • To investigate the presence and distribution of somatostatin receptors in various human tumors.
  • To explore the potential of somatostatin receptors as therapeutic targets in oncology.

Main Methods:

  • Autoradiography was used to visualize somatostatin receptors.
  • Biochemical characterization was performed on receptor-positive tissues and tumors.

Main Results:

  • High incidence of somatostatin receptors was found in GH-producing pituitary adenomas and some gastrointestinal tumors.
  • Meningiomas typically showed a high density of somatostatin receptors.
  • Prostate, ovarian, and endometrial carcinomas lacked these receptors, while a small fraction of mammary tumors did.

Conclusions:

  • Somatostatin receptors are present in specific human tumors, indicating their potential role in tumor biology.
  • The high receptor density in certain tumors suggests that somatostatin analogs could be effective therapeutic agents for these conditions.

More Related Videos

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice08:55

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity06:16

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

Published on: December 8, 2019

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...