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Induction of double-strand breaks following neutron capture by DNA-bound 157Gd
R F Martin1, G D'Cunha, M Pardee
1Molecular Science Group, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia.
International Journal of Radiation Biology
|August 1, 1988
Abstract:
Irradiation of plasmid DNA/Gd3+ mixtures with thermal neutrons induces DNA double-strand breaks (dsb). However, the extent of breakage is markedly reduced by sequestering the Gd3+ from DNA by addition of EDTA. Since the 157Gd neutron capture event involves some internal conversion, we suggest that the DNA dsb induction results from Auger electron emission.