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Updated: Aug 28, 2026

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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Differential displacement of opioids from plasma protein binding sites by di-isopropylfluorophosphate in the mouse
The Journal of Pharmacy and Pharmacology
|April 1, 1988
Abstract:
Di-isopropylfluorophosphate (DFP) displaced the opioid drug, alfentanil, from plasma proteins in-vivo and in-vitro in mice but was without effect on the structurally related compound, fentanyl. This action probably accounts for the enhanced entry of alfentanil into the brain of DFP-treated animals and its enhanced antinociceptive activity.
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