Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The human gene map.

E B Robson1

  • 1Galton Laboratory, University College London, U.K.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|June 15, 1988
PubMed
Summary
This summary is machine-generated.

Human gene mapping, initiated 50 years ago, now enables prenatal diagnosis for several diseases. Advances in recombinant DNA technology have significantly improved genetic mapping and understanding of genome organization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The use of the placenta in human biochemical genetics with special reference to twin placentation and zygosity [summary].

Proceedings of the Royal Society of Medicine·2010
Same author

Two loci for tuberous sclerosis: one on 9q34 and one on 16p13.

Annals of human genetics·1994
Same author

The CEPH consortium linkage map of human chromosome 2.

Genomics·1992
Same author

Guidelines for human linkage maps: an international system for human linkage maps (ISLM, 1990).

Genomics·1991
Same author

Guidelines for human linkage maps. An International System for Human Linkage Maps (ISLM, 1990).

Annals of human genetics·1991
Same author

The CEPH consortium primary linkage map of human chromosome 10.

Genomics·1990
Same journal

The microlandscapes of tree trunks: the effect of lichen and tree-level characteristics on arthropod communities.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Centimetre-scale landscapes to assess the motion behaviour and cognition of gastropods and bivalves.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Intertidal microcosms of wave-swept rocky shores: ecological and physiological insights from a uniquely stressful environment.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Temporal and spatial variation in temperature and oxygen at the microscale: key niche axes for aquatic life.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Natural microcosms in ecology: fulfilling the promise of model systems?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Microbe-induced galls and plant defence: metabolite crosstalk in a co-evolutionary battle.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
See all related articles

Area of Science:

  • Genetics
  • Molecular Biology
  • Human Genome Research

Background:

  • Genetic linkage analysis, pioneered by Bell & Haldane in 1937, aimed to predict disease inheritance.
  • Early genetic mapping relied on family studies and somatic-cell hybridization for gene assignment.

Purpose of the Study:

  • To review the historical development and current applications of human gene mapping.
  • To highlight the impact of recombinant DNA technology on genetic mapping and disease prediction.

Main Methods:

  • Historical review of genetic mapping techniques.
  • Application of recombinant DNA technology in gene linkage and assignment.
  • Somatic-cell hybridization for chromosome mapping.

Main Results:

Related Experiment Videos

  • Significant progress in creating rough maps for many human chromosomes.
  • Development of prenatal diagnostic tools for genetic diseases.
  • Identification of potential starting points for molecular studies of undefined genes.

Conclusions:

  • Human gene mapping has evolved from basic linkage studies to sophisticated molecular approaches.
  • Current genetic maps facilitate prenatal diagnosis and offer insights into meiotic processes and genome organization.