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Scrapie: a virus-induced amyloidosis of the brain
H Diringer1, H R Braig, M Czub
1Robert Koch-Institut des Bundesgesundheitsamtes, Berlin, Federal Republic of Germany.
Ciba Foundation Symposium
|January 1, 1988
Abstract:
We have studied the pathogenesis of scrapie in hamsters, in particular the increase of infectivity and the formation of scrapie-associated fibrils in relation to clinical disease. The results of such studies after intraperitoneal or intracerebral infection are consistent with the idea that transmissible spongiform encephalopathies are a type of virus-induced, brain-specific amyloidosis. Therefore, an appropriate name for the class of viruses that cause these diseases might be amyloid-inducing viruses.