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A simple and rapid method to screen for mutant mice lacking D-amino-acid oxidase activity
1Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan.
Laboratory Animal Science
|June 1, 1988
Abstract:
A simple and rapid method to screen for mutant mice (Mus musculus) lacking D-amino-acid oxidase activity has been devised. Mice were given water containing small amounts (0.02%) of either D-methionine or D-phenylalanine. Urinary levels of the D-amino acid were examined using thin-layer chromatography. Some mice excreted substantial amounts of the D-amino acid through the urine. None of them had detectable D-amino-acid oxidase activity.