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Cryo-electron Microscopy

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...

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Related Experiment Video

Updated: Feb 21, 2026

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

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Comparative Notes on the Cryoscopy of Milk

¹Public Analyst to the Government of Burma. Harcourt Butler Institute of Public Health, Rangoon.

The Indian Medical Gazette

|October 11, 2017

Summary

No abstract available in PubMed .

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