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N-terminal amino acid sequence analysis indicates that isolated atrial amyloid is derived from atrial natriuretic
R P Linke1, C Voigt, F S Störkel
1Institut für Immunologie der LM-Universität, München, Federal Republic of Germany.
Virchows Archiv. B, Cell Pathology Including Molecular Pathology
|January 1, 1988
Abstract:
Isolated atrial amyloid, the most frequent senile cardiac amyloid type, was chemically analysed. Amyloid fibrils obtained from a patient (NIP) were extracted and the predominant low-molecular-weight polypeptide (approximately 3.5 kDa, designated ASc2 NIP) was isolated by size exclusion high performance liquid chromatography in 60% formic acid. N-Terminal amino acid sequence analysis of this polypeptide was identical to that of the atrial natriuretic peptide alpha-hANP for the first 12 residues determined.