Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple myeloma associated with multilobated plasma cell nuclei.

D H Buss1, G D Reynolds, M R Cooper

  • 1Department of Pathology, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, NC 27103.

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
|January 1, 1988
PubMed
Summary

This study reports on 10 multiple myeloma cases with unusual plasma cell nuclear morphology. These findings highlight diagnostic challenges and the need for advanced techniques to confirm B-cell lineage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma.

Leukemia·2016
Same author

Alteration of fibrous capsule formation by use of immunomodulation.

Aesthetic surgery journal·2009
Same author

Phase III study of cyclophosphamide, doxorubicin, and fluorouracil (CAF) plus leucovorin versus CAF for metastatic breast cancer: Cancer and Leukemia Group B 9140.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2003
Same author

Fatal EBV-related post-transplant lymphoproliferative disorder (LPD) after matched related donor nonmyeloablative peripheral blood progenitor cell transplant.

Bone marrow transplantation·2003
Same author

Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2002
Same author

Cancer control and the Central Cancer Registry of North Carolina.

North Carolina medical journal·2001

Area of Science:

  • Hematology
  • Oncology
  • Cell Biology

Background:

  • Multiple myeloma is a malignancy of plasma cells.
  • Nuclear morphology is a key diagnostic feature.
  • Atypical nuclear features can complicate diagnosis.

Purpose of the Study:

  • To describe 10 cases of multiple myeloma with excessively convoluted or lobulated plasma cell nuclei.
  • To evaluate the diagnostic implications of this nuclear morphology.
  • To discuss the utility of advanced techniques for confirming cell lineage.

Main Methods:

  • Retrospective review of 297 multiple myeloma cases over 22 years.
  • Morphological analysis of plasma cells.
  • Ultrastructural examination of 2 cases.

Related Experiment Videos

  • Immunoperoxidase staining and electron microscopy were considered for diagnosis.

    • Main Results:

    • Ten cases (3%) exhibited plasma cells with markedly convoluted/lobulated nuclei.
    • All 10 patients had advanced stage disease and a mean survival of 19.5 months.
    • These cells can mimic other cell types, posing diagnostic challenges.

    Conclusions:

    • Excessive nuclear convolution in plasma cells can be a feature of multiple myeloma.
    • Diagnostic confirmation may require immunoperoxidase staining or electron microscopy.
    • Nuclear convolution alone is not a reliable indicator of T-cell versus B-cell lineage.