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Types of Typhoidphage and a Note on the Protective Value of Typhoidphage in Animal Experiments

C L Pasricha1, M N Lahiri2, D N Chatterjee2

  • 1MAJOR, I.M.S. (From the Bacteriological Department, School of Tropical Medicine, Calcutta).

The Indian Medical Gazette
|October 11, 2017
PubMed
Abstract

No abstract available in PubMed .

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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