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Xenobiotic metabolism in motor neuron disease
G Steventon1, A C Williams, R H Waring
1Department of Neurology, Queen Elizabeth Medical Centre.
Lancet (London, England)
|September 17, 1988
Abstract:
Debrisoquine, carbocysteine, and paracetamol were selected as safe drugs to investigate the ability of the liver's microsomal system to oxidise carbon, oxidise sulphur, and conjugate sulphate in patients with motor neuron disease (MND), other hospital patients, and healthy volunteers. Subjects with poor sulphur-oxidising and sulphur-conjugating activities were heavily over-represented in the MND group.