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Related Concept Videos

Bone Disorders01:29

Bone Disorders

5.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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The Functions of the Skeletal System01:22

The Functions of the Skeletal System

6.1K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Bone Remodeling01:40

Bone Remodeling

40.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.6K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.3K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.3K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

14.1K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
14.1K
Inflammation01:38

Inflammation

62.6K
Overview
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Related Experiment Video

Updated: Feb 21, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

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Inflammation in bone physiology and pathology.

Iannis E Adamopoulos1,2

  • 1Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis.

Current Opinion in Rheumatology
|October 11, 2017
PubMed
Summary
This summary is machine-generated.

Inflammation influences bone remodeling, impacting bone loss and formation. Harnessing these inflammatory signals shows great potential for advancing bone regeneration strategies.

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Area of Science:

  • Bone biology and regeneration
  • Inflammatory processes in skeletal tissue

Background:

  • Bone remodeling is a continuous process involving anabolic and catabolic actions essential for tissue homeostasis.
  • Hormones, growth factors, and cellular interactions regulate bone remodeling.
  • Inflammatory changes in the bone microenvironment can lead to abnormal bone loss or formation.

Purpose of the Study:

  • To review the current understanding of inflammation's role in bone resorption and formation.
  • To explore the potential of utilizing inflammatory signals for bone regeneration.

Main Methods:

  • Review of recent scientific literature on inflammation and bone biology.
  • Analysis of mechanisms linking inflammatory signals to bone cell differentiation and activity.

Main Results:

  • Inflammatory signals can stimulate transcription factors that promote osteoblast differentiation from precursor cells.
  • Inflammation contributes to various bone disorders through altered resorption and formation processes.

Conclusions:

  • Understanding the intricate roles of inflammation in bone is crucial for developing new therapeutic approaches.
  • Inflammatory pathways offer significant potential for harnessing and directing bone regeneration.