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Updated: Feb 21, 2026
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
ACUTE MACULAR NEURORETINOPATHY AND PERIPHERAL RETINAL VASCULAR ABNORMALITIES IN A PATIENT BORN HIV SEROPOSITIVE
Chiara Giuffrè1, Alessandro Rabiolo1, Eleonora Corbelli1
1Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy.
Purpose:
To describe the case of a born HIV seropositive woman who developed outer retinal alterations secondary to vascular abnormalities in the perimacular region and in the periphery of both eyes.
Methods:
Case report.
Results:
A 21-year-old woman born HIV seropositive was referred for a routinary visit. Her best-corrected visual acuity was 20/20 in both eyes, and during the visit, only mild superotemporal metamorphopsia in the left eye was reported. Multimodal imaging disclosed findings consistent with acute macular neuroretinopathy such as reddish-brown lesions at fundus examination and disruption of ellipsoid zone at spectral domain optical coherence tomography. Peripheral vascular alterations were also noted at fluorescein angiography.
Conclusion:
Several associations or risk factors have been identified in patients with acute macular neuroretinopathy, including oral contraceptives, epinephrine/ephedrine, or systemic shock. To the best of our knowledge, this is the first case describing peripheral vascular alterations and acute macular neuroretinopathy in association with HIV seropositivity at birth.
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