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Learning impairment in rats by N-methyl-D-aspartate receptor antagonists
W Danysz1, J T Wroblewski, E Costa
1Fidia-Georgetown Institute for the Neurosciences, Georgetown University School of Medicine, Washington, D.C. 20007.
Neuropharmacology
|June 1, 1988
Abstract:
2-Amino-5-phosphonovalerate (APV, icv) phencyclidine (PCP, ip) and scopolamine (sc) dose-dependently disrupted short term working memory in radial maze. These drugs injected before, but not after training attenuated retention of long term memory in passive avoidance task. A relation of PCP action to its antagonism at NMDA receptors may be suggested.