Noninvasive detection of focal brain hyperthermia related to continuous epileptic activities using proton MR
Daichi Sone1, Naoki Ikegaya2, Akio Takahashi2
1Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan; Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8654, Japan.
Abstract:
Recent studies using rat models suggested that epileptic discharges (EDs) can induce focal brain hyperthermia, but such ED-related hyperthermia has not been confirmed in humans. We examined hyperthermia of the focus of epilepsy using noninvasive proton magnetic resonance spectroscopy (1H-MRS) thermometry. We recruited six pediatric patients with refractory daily seizures, continuous interictal epileptic discharges, and concordant focus lesions on MRI who had undergone comprehensive presurgical exams. 1H-MRS thermometry calculated the temperatures of the presumed epileptogenic lesions, and we examined the contralateral counterparts in each patient as controls. As a result, the mean temperature of the epileptogenic foci (36.81°C) was significantly higher than that of the controls (36.01°C). The mean difference was 0.81°C (95%CI: 0.22-1.39, p=0.017). 1H-MRS thermometry may have the ability to noninvasively detect focal brain hyperthermia related to continuous EDs in human subjects, and to contribute to a better understanding and focus detection of epilepsy.
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