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Lifetime Risks, Projected Numbers, and Adverse Outcomes in Asian Patients With Atrial Fibrillation: A Report From the
Tze-Fan Chao1, Chia-Jen Liu2, Ta-Chuan Tuan1
1Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine and Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan.
Chest
|October 12, 2017
Summary
The lifetime risk of atrial fibrillation (AF) in Asians is 1 in 7, with increasing prevalence projected. AF significantly elevates risks for mortality, heart failure, stroke, and dementia, necessitating comprehensive management.
Area of Science:
- Cardiology
- Epidemiology
- Public Health
Background:
- Limited data exist on the clinical epidemiology of atrial fibrillation (AF) in Asian populations.
- This study investigates the lifetime risk and projected prevalence of AF among Asians.
- It also analyzes adverse event risks associated with AF compared to non-AF patients.
Purpose of the Study:
- To determine the lifetime risk and projected prevalence of atrial fibrillation in the Asian population.
- To analyze the risks of adverse events in patients with AF.
- To compare these risks with age- and sex-matched individuals without AF.
Main Methods:
- Analysis of new-onset AF cases among 289,559 patients aged ≥20 years in Taiwan (2000-2011).
- Calculation of AF incidence, prevalence, and lifetime risk.
- Comparative analysis of adverse event risks between AF and non-AF patient cohorts.
Main Results:
- The incidence of AF in 2011 was 1.51 per 1,000 person-years.
- The lifetime risk of AF for individuals over 20 is approximately 1 in 7.
- AF patients showed significantly increased risks of mortality (aHR 2.61), heart failure (aHR 3.31), ischemic stroke (aHR 3.34), dementia (aHR 1.56), sudden cardiac death (aHR 1.83), and myocardial infarction (aHR 1.62).
- Elevated risks for stroke, heart failure, and mortality were particularly pronounced within 6 months post-diagnosis.
Conclusions:
- The burden of atrial fibrillation in Asian patients is growing, with a substantial lifetime risk.
- Effective management of AF requires addressing associated comorbidities.
- Holistic management strategies are crucial for improving outcomes in AF patients.
