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Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
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JAKE® Multimodal Data Capture System: Insights from an Observational Study of Autism Spectrum Disorder.
Seth L Ness1, Nikolay V Manyakov2, Abigail Bangerter1
1Neuroscience Therapeutic Area, Janssen Research and Development, Titusville, NJ, United States.
Frontiers in Neuroscience
|October 12, 2017
Summary
The Janssen Autism Knowledge Engine (JAKE®) system shows promise for autism spectrum disorder (ASD) clinical trials. Optimized components and biosensors like eye-trackers and sleep monitors are viable for objective symptom measurement.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Clinical Trials
Background:
- Autism Spectrum Disorder (ASD) diagnosis and monitoring require objective measures.
- Current clinical trial methods for ASD can be enhanced with technology.
- The Janssen Autism Knowledge Engine (JAKE®) system aims to provide objective data.
Purpose of the Study:
- To assess the usability and optimize the JAKE® system for ASD clinical trials.
- To evaluate biosensors and procedures for measuring ASD symptoms objectively.
- To establish the feasibility and practical implementation of the JAKE® system.
Main Methods:
- A prospective, observational study involving 29 children and adolescents with ASD.
- Utilized JAKE® system's web, mobile, and wearable biosensor components.
- Collected continuous and task-based biosensor data (eye-tracker, sleep monitor, ECG, EEG) and parent-reported measures (ABI).
Main Results:
- System feedback enabled planned refinements for all JAKE® components.
- The Autism Behavior Inventory (ABI) demonstrated good performance.
- Eye-tracker, sleep monitor, and ECG provided high-quality data; wireless EEG had usability challenges.
- Most parents reported a positive overall experience with JAKE®; no device-related events occurred.
Conclusions:
- The JAKE® system is a viable, useful, and safe platform for ASD clinical trials.
- Optimized JAKE® system components and biosensors facilitate objective symptom measurement.
- Further validation and deployment studies are warranted for the refined JAKE® system.
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