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Rod metabolic demand drives progression in retinopathies
Michael K Lin1, Soo Hyun Kim2, Lijuan Zhang3
1College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Taiwan Journal of Ophthalmology
|October 12, 2017
Abstract:
Various factors are thought to cause the development and progression of disease in macular degeneration, diabetic retinopathy, and retinitis pigmentosa. Some of the deleterious processes include oxidative stress, hypoxia, metabolic derangement, genetics, and vasculopathy. In this review, we present a unified theory for the pathophysiology of several retinopathies based on the unique and intense metabolism of rod photoreceptors.

