Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

2.0K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.0K
Plasticity00:58

Plasticity

3.2K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and tolerability of nutraceuticals and phytotherapics for antipsychotic-induced weight gain in schizophrenia spectrum disorders: Systematic review and meta-analysis.

Pharmacopsychiatry·2026
Same author

The Role of Emotion Dysregulation, Impulsiveness and Rumination in Psychopathology: Evidence from an Italian Sample of Adolescents and Young Adults.

Brain sciences·2026
Same author

Cannabidiol for the treatment of positive and negative symptoms in schizophrenia spectrum disorders: a systematic review and meta-analysis.

European archives of psychiatry and clinical neuroscience·2026
Same author

Anxiety-Related Functional Dizziness: A Systematic Review of the Recent Evidence on Vestibular, Cognitive Behavioral, and Integrative Therapies.

Life (Basel, Switzerland)·2026
Same author

Relationships Among Bullying Experiences, Mood Symptoms and Suicidality in Subjects with and Without Autism Spectrum Conditions.

Brain sciences·2025
Same author

Antidepressant and Related Neurobiological and Neurophysiological Effects of Add-On Transcranial Direct Current Stimulation in Major Depressive Disorder with Residual Symptoms: A Randomized, Double-Blind Clinical Trial Protocol.

Methods and protocols·2025

Related Experiment Video

Updated: Feb 21, 2026

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation
12:26

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation

Published on: June 2, 2018

8.3K

Hypericum perforatum extract modulates cortical plasticity in humans.

Carmen Concerto1, Hyunji Boo2, Charles Hu2

  • 1Department of Interprofessional Health Sciences and Health Administration, School of Health and Medical Sciences, Seton Hall University, 400 South Orange Avenue, South Orange, NJ, 07079, USA.

Psychopharmacology
|October 12, 2017
PubMed
Summary

A single dose of Hypericum perforatum (HYP) extract altered brain plasticity in healthy individuals. This herbal remedy reversed specific brain plasticity effects, offering insights into its mechanism for depression treatment.

Keywords:
Cortical plasticityHypericum perforatum extractTMStDCS

More Related Videos

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation
08:29

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation

Published on: November 7, 2025

433
Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
09:29

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Published on: July 10, 2019

11.7K

Related Experiment Videos

Last Updated: Feb 21, 2026

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation
12:26

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation

Published on: June 2, 2018

8.3K
Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation
08:29

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation

Published on: November 7, 2025

433
Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
09:29

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Published on: July 10, 2019

11.7K

Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Integrative Medicine

Background:

  • Hypericum perforatum (HYP) extract is a widely used herbal remedy for mild-to-moderate depression.
  • Non-invasive brain stimulation techniques allow investigation of psychoactive substance effects on the brain.

Purpose of the Study:

  • To investigate the impact of a single oral dose of HYP extract (WS 5570) on human corticospinal excitability and plasticity.
  • To explore the potential mechanisms of action for HYP extract in modulating brain function.

Main Methods:

  • Twenty-eight healthy subjects received either 900 mg of HYP extract or a placebo.
  • Cortical excitability was assessed using transcranial magnetic stimulation (TMS) measures (motor threshold, MEP recruitment, CSP, SICI, ICF).
  • Cortical plasticity was induced via transcranial direct current stimulation (tDCS), with plasticity assessed by motor-evoked potential (MEP) amplitudes.

Main Results:

  • HYP extract reversed cathodal tDCS-induced long-term depression (LTD)-like plasticity into facilitation compared to placebo.
  • No significant effects of HYP extract were observed on anodal tDCS-induced plasticity.
  • HYP extract did not significantly alter TMS measures of motor cortex excitability or spinal/neuromuscular excitability.

Conclusions:

  • A single oral dose of HYP extract modulates cortical plasticity in healthy individuals.
  • These findings provide novel insights into the neurobiological mechanisms underlying the effects of HYP extract.
  • This research contributes to understanding the therapeutic potential of herbal medicines in neurological and psychiatric conditions.