Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Narcolepsy01:07

Narcolepsy

602
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
602
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

3.0K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.0K
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

7.5K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
7.5K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.7K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.7K
Regulation of Heart Rates01:31

Regulation of Heart Rates

4.2K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
4.2K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

594
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
594

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Intelligence for Sleep Instability and Motor Phenotyping: Clinical Translation Beyond Sleep Staging.

Sleep·2026
Same author

Beyond the Sleep Lab: A Narrative Review of Wearable Sleep Monitoring.

Bioengineering (Basel, Switzerland)·2025
Same author

Narcolepsy and risk of cardiovascular outcomes: getting to the heart of the matter.

Sleep·2025
Same author

Long lasting effects of perinatal exposure to the Chlorpyrifos pesticide on sleep, breathing, and neuroinflammation in adult mice.

PloS one·2025
Same author

Autonomic correlates of large muscle group movements during non-REM sleep in restless legs syndrome: a comparative analysis with periodic and non-periodic leg movements.

Sleep·2025
Same author

Probability estimation of narcolepsy type 1 in DTA mice using unlabeled EEG and EMG data.

Sleep advances : a journal of the Sleep Research Society·2025

Related Experiment Video

Updated: Feb 21, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

10.6K

The link between narcolepsy and autonomic cardiovascular dysfunction: a translational perspective.

Chiara Berteotti1, Alessandro Silvani2

  • 1Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126, Bologna, Italy.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|October 12, 2017
PubMed
Summary

Narcolepsy with cataplexy (NC) involves autonomic cardiovascular dysfunction, impacting heart rate and blood pressure regulation due to orexin deficiency. Further research is needed to understand its effect on cardiovascular risk.

Keywords:
Blood pressureHeart rate variabilityMiceRatsSleep

More Related Videos

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

8.3K
Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
06:40

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

Published on: May 22, 2018

11.3K

Related Experiment Videos

Last Updated: Feb 21, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

10.6K
Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

8.3K
Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
06:40

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

Published on: May 22, 2018

11.3K

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology
  • Sleep Medicine

Background:

  • Narcolepsy with cataplexy (NC) is a rare neurological disorder characterized by excessive daytime sleepiness and cataplexy.
  • It results from the loss of orexin-producing neurons in the hypothalamus.
  • Orexin neurons influence sleep-wake states and autonomic functions.

Purpose of the Study:

  • To review the relationship between narcolepsy with cataplexy and autonomic cardiovascular dysfunction.
  • To provide a translational perspective on these links.

Main Methods:

  • Review of existing literature and evidence from patients and animal models.
  • Analysis of heart rate and arterial blood pressure data during wakefulness and sleep.

Main Results:

  • Patients and animal models with NC exhibit altered heart rate variability during wakefulness and sleep.
  • Responses of heart rate to stimuli like arousal are blunted.
  • Blood pressure regulation is impaired, with a blunted fall during sleep, particularly REM sleep, and variable decreases during wakefulness.

Conclusions:

  • Orexin deficiency in NC leads to autonomic cardiovascular dysfunction, affecting heart rate and blood pressure.
  • The precise impact on cardiovascular risk in narcolepsy patients requires further investigation.