Related Experiment Video
Updated: Feb 21, 2026

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
Published on: August 16, 2019
Children with type 1 Diabetes Mellitus: access to special immunobiological and child care
Paula Carolina Bejo Wolkers1, Marina Sayuri Yakuwa2, Letícia Pancieri2
1Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
Insights
Many mothers of children with type 1 diabetes mellitus face challenges accessing specialized childcare and vaccinations. Misinformation and administrative hurdles lead to missed vaccination opportunities, highlighting gaps in healthcare access.
Area of Science:
- Pediatric Endocrinology
- Public Health
- Immunization Practices
Background:
- Children with type 1 diabetes mellitus (TDM1) have specific health needs, including timely vaccinations.
- Access to specialized childcare and understanding vaccination rights are crucial for managing TDM1 in children.
Purpose of the Study:
- To identify childcare utilization, vaccination status, and reasons for non-vaccination in children with TDM1.
- To assess mothers'/guardians' understanding of the right to special vaccines for children with TDM1.
Main Methods:
- A descriptive, cross-sectional study involving interviews with 47 mothers/guardians.
- Data collection focused on childcare access and vaccination against influenza and pneumococcal 23-valent (PPSV).
Main Results:
- Few participants regularly used basic healthcare child care, preferring specialized services.
- Incomplete vaccination schedules, delayed follow-ups, and missing vaccination cards were common.
- Misinformation regarding vaccine necessity and administrative requirements led to missed vaccination opportunities.
Conclusions:
- Significant fragilities exist in child care and immunization services for children with TDM1.
- Enhancing primary healthcare, strengthening the care network, and promoting awareness of health rights are essential to improve evidence-based practice and access to care.
Objectives:
Identifying the use of child care situations, the vaccination situation and the reasons for non-vaccination, and characterizing whether mothers/guardians demonstrate notions about the right to special vaccines for children with type 1 Diabetes Mellitus.
Method:
A descriptive, cross-sectional study with analysis of quantitative data based on interviews with mothers/guardians, particularly regarding access to childcare and vaccination against influenza and pneumococcal 23-valent (PPSV).
Results:
47 mothers/guardians participated in the study. The participants reported using more specialized services to follow child health, and only a few used the child care of the basic health care regularly. There were incomplete vaccination schedules, delayed annual follow-ups, missing vaccination cards at the consultations, misinformation about the special character of the vaccination, as well as emphasis on the need of presenting a specific form to obtain the vaccination, resulting in discontinuation of health actions and missed opportunities for vaccination.
Conclusion:
Fragilities in child care and immunization actions require an increase of primary health care and of the care network, based on knowledge and the right to health in order to expand the evidence-based practice, access and comprehensiveness.
Related Concept Videos
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

