X-ray dynamic observation of cervical degenerative disease induced by unbalanced dynamic and static forces in rats 1
Hua Xie1, Yongjing Huang2, Luming Nong3
1PhD, Department of Orthopedics, Jintan People's Hospital, Jiangsu, P.R. China. Manuscript preparation and writing.
Purpose:
To investigate dynamically the X-ray appearance of cervical degenerative disease induced by unbalanced dynamic and static forces in rats.
Methods:
A total of 60 Sprague Dawley rats were randomized into test (n=45) and control (n=15) groups, which were randomly subdivided into the one-, three- and six-month post-operative groups. The test group included 10, 15 and 20 rats at the respective corresponding post-operative stage and the control group included five rats at each time-point. By excising cervicodorsal muscles, interspinous ligaments and supraspinous ligament of rats in the test group, the balance of dynamic and static forces on cervical vertebrae was disrupted to establish a rat model of cervical degeneration. Spinal X-ray images were acquired, and intervertebral disc space and intervertebral foramen size were measured at one, three and six months post-operation. The results were analyzed and compared among groups.
Results:
Cervical dynamic and static imbalance accelerated the appearance of cervical degenerative disease on X-ray.
Conclusion:
Cervical degenerative disease may be induced by unbalanced dynamic and static forces in rats.
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