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Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing

Anne Piantadosi1,2,3, Sanjat Kanjilal1,2, Vijay Ganesh4

  • 1Division of Infectious Diseases, Massachusetts General Hospital.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|October 12, 2017
PubMed

Insights

Rapid metagenomic sequencing identified Powassan virus, a tick-borne flavivirus, as the cause of severe encephalitis in a US patient. This finding highlights the virus as an emerging cause of neurological disease.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Virology

Background:

  • Encephalitis is a severe neurological condition often with unknown causes.
  • Tick-borne flaviviruses are an increasing public health concern in the United States.

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