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Updated: Feb 21, 2026

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
[Influence of thyroid dysfunction on male sexual and reproductive functions and its mechanisms]
Yin-ming Li1,2, Bing Yao1
1Center of Reproductive Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
Abstract:
Thyroid dysfunction may affect the body growth metabolism and the synthesis and secretion of sex steroids. A large number of clinical and basic studies suggest that thyroid hormone abnormality can cause sexual and reproductive problems. Patients with hyperthyroidism or hypothyroidism may develop not only premature ejaculation but also erectile dysfunction. The thyroid hormone level also influences Leydig cells, Sertoli cells, and spermatogenesis. This review focuses on the association of thyroid dysfunction with male premature ejaculation, erectile dysfunction, and infertility and its mechanisms.
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