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Updated: Feb 21, 2026

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
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Genetic Constructor: An Online DNA Design Platform.

Maxwell Bates1, Joe Lachoff1, Duncan Meech1

  • 1Autodesk Life Sciences , San Francisco, California 94111, United States.

ACS Synthetic Biology
|October 13, 2017
PubMed
Summary
This summary is machine-generated.

Genetic Constructor is a cloud-based CAD tool for synthetic biology, simplifying DNA design and fabrication. This open-source platform democratizes access to synthetic biology tools and services for researchers.

Keywords:
CADbiological designcloud foundryopen sourcesoftwaresynthetic biology

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Area of Science:

  • Synthetic Biology
  • Bioinformatics
  • Computer-Aided Design (CAD)

Background:

  • Synthetic biology requires sophisticated tools for designing and fabricating DNA constructs.
  • Current design workflows can be complex, hindering rapid iteration and accessibility.

Purpose of the Study:

  • To introduce Genetic Constructor, a cloud-based CAD application for synthetic biology.
  • To streamline the design, management, and iteration of DNA constructs and libraries.

Main Methods:

  • Development of a cloud-based CAD application with a novel visual language focusing on functional parts.
  • Implementation of features such as combinatorial libraries and automated primer design.
  • Inclusion of a plugin architecture for extensibility and integration with DNA fabrication services.

Main Results:

  • Genetic Constructor facilitates the separation of design intent from DNA construction.
  • The platform supports iterative design refinement through design constraints.
  • It offers accessibility, platform agnosticism, and an open-source community edition.

Conclusions:

  • Genetic Constructor democratizes DNA design and manufacturing for the synthetic biology community.
  • The tool enhances accessibility to advanced synthetic biology tools and services.
  • It supports efficient design-to-fabrication workflows and collaborative development.