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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Early adversity and psychiatric symptoms - a prospective study on Ethiopian mothers and their children
Johan Isaksson1,2, Negussie Deyessa3, Yemane Berhane4
1Department of Neuroscience, Child and Adolescent Psychiatry Unit, Uppsala University, Uppsala, Sweden. johan.isaksson@neuro.uu.se.
Insights
Maternal perinatal stressors did not increase offspring psychiatric symptoms in this Ethiopian cohort. However, intimate partner violence (IPV) is a significant public health issue affecting maternal mental health.
Area of Science:
- Perinatal mental health
- Child psychology
- Public health
Background:
- Maternal perinatal adversity is linked to offspring psychiatric issues.
- Investigating developmental impacts of maternal stressors in a developing country.
Purpose of the Study:
- To examine the developmental effects of maternal perinatal stressors on offspring emotional and behavioral symptoms.
- To assess the role of intimate partner violence (IPV) and maternal psychiatric symptoms.
Main Methods:
- Followed an Ethiopian birth cohort (N=358) for 10 years.
- Assessed intimate partner violence (IPV) and maternal psychiatric symptoms during perinatal period and at follow-up.
- Used maternal ratings on the Child Behavior Checklist (CBCL) at 10-year follow-up.
Main Results:
- Intimate partner violence (IPV) exposure was common (60.6%) and predicted future IPV.
- Maternal psychiatric symptoms at perinatal and follow-up were associated.
- Current maternal anxiety and depression symptoms, not perinatal symptoms, correlated with child CBCL scores.
Conclusions:
- Early adversity did not increase susceptibility to psychiatric symptoms in offspring.
- Intimate partner violence (IPV) is a major public health concern impacting maternal mental health.
Background:
Maternal exposure to adversity during the perinatal period has been associated with increased susceptibility for psychiatric symptoms in the offspring. The aim of this study was to investigate a possible developmental effect of maternal perinatal stressors on emotional and behavioural symptoms in the offspring in a developing country.
Methods:
We followed an Ethiopian birth cohort (N = 358), assessing intimate partner violence (IPV) and maternal psychiatric symptoms during the perinatal period and at follow-up 10 years later, as a proxy for adversity, and maternal ratings on the Child Behavior Checklist (CBCL) 10 years later as the outcome.
Results:
Among the women, exposure to IPV was common (60.6%) during the perinatal period and predicted IPV (29.9% of the mothers) at follow-up (ρ = 0.132; p = 0.012). There was also an association between maternal psychiatric symptoms at the two time points (ρ = 0.136; p = 0.010) and between maternal symptoms and IPV. Current maternal symptoms of anxiety and depression (β = 0.057; p < 0.001), but not during the perinatal period, were associated with child CBCL-scores.
Conclusion:
Our findings do not support the hypothesis that early adversity increase susceptibility for psychiatric symptoms. However, the findings emphasize the public health problem of IPV in this population, adding to the women's mental health problem.
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