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Network-based approaches to quantify multicellular development.

Matthew D B Jackson1, Salva Duran-Nebreda1, George W Bassel2

  • 1School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.

Journal of the Royal Society, Interface
|October 13, 2017
PubMed
Summary
This summary is machine-generated.

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Understanding how cells organize in organs is crucial for organ function. New methods analyze cellular arrangements to reveal evolutionary patterns and guide future organ design.

Area of Science:

  • Developmental Biology
  • Systems Biology
  • Evolutionary Biology

Background:

  • Multicellularity enables novel organ functions through structure-function relationships.
  • While cell behaviors like migration and division are studied, higher-order cellular organization in organs remains less understood.
  • The functional coordination of organs via global spatial relations is key to their development and constraints.

Purpose of the Study:

  • To investigate the reasons behind specific cellular organization patterns in organs.
  • To determine the evolutionary significance of selected cellular organization patterns.
  • To explore alternative possible configurations of cellular organization.

Main Methods:

  • Utilizing global cellular interaction mapping and network science to analyze organ structure and function.
Keywords:
complexitydevelopmentmulticellularitynetwork scienceself-organizationstructure–function

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  • Discretizing and analyzing global cellular organization to create a quantitative framework for studying developmental processes.
  • Leveraging advances in high-resolution microscopy and image analysis for cellular interaction mapping.

    • Main Results:

    • A quantitative framework was developed to analyze local and global properties of multicellular systems.
    • The approach allows for discrete analysis and comparison of cellular organization across different tissues and models.
    • Cellular interaction mapping is becoming increasingly feasible across diverse biological systems.

    Conclusions:

    • Understanding higher-order properties of cellular assemblies offers insights into the evolution and constraints of cell organization.
    • Establishing structure-function relationships in cellular organization can guide future organ design.
    • This approach provides a quantitative method to explore developmental processes and evolutionary patterns in organ development.