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Related Concept Videos

Development of the Lymphatic System01:15

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Updated: Feb 21, 2026

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Lymphatic Endothelial Cell Plasticity in Development and Disease.

Wanshu Ma1, Guillermo Oliver1

  • 1Center for Vascular & Developmental Biology, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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This review explores how lymphatic endothelial cells (LECs) develop and how their fate can be altered. Understanding LEC plasticity offers potential therapeutic strategies for lymphatic disorders.

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Area of Science:

  • Developmental Biology
  • Vascular Biology
  • Cell Biology

Background:

  • The lymphatic vasculature is vital for fluid balance, immunity, and lipid absorption.
  • Lymphatic endothelial cells (LECs) share the blood vasculature but have unique characteristics.
  • Differentiated endothelial cells (ECs) show significant heterogeneity and plasticity.

Purpose of the Study:

  • To review molecular mechanisms of lymphatic cell fate specification in mammalian embryos.
  • To summarize evidence on the reprogrammability of lymphatic EC fate.
  • To discuss therapeutic potential of manipulating lymphatic EC fate.

Main Methods:

  • Literature review of molecular mechanisms in embryonic development.
  • Synthesis of data on lymphatic EC plasticity in health and disease.
  • Discussion of cell fate manipulation for treating lymphatic disorders.

Main Results:

  • Molecular mechanisms guide lymphatic cell fate specification during embryonic development.
  • Lymphatic EC fate is demonstrated to be reprogrammable.
  • Evidence suggests plasticity in both normal and pathological conditions.

Conclusions:

  • Understanding lymphatic EC development and plasticity is key.
  • Cell fate reprogramming holds promise for treating lymphatic dysfunction.
  • Targeting lymphatic EC plasticity could lead to novel therapeutic approaches.