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Related Concept Videos

Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
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Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

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Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
654
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

740
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

1.4K
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Related Experiment Video

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Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
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Crizotinib-induced Rectal Perforation with Abscess.

Asako Yanagisawa1, Noriko Hayama1, Hiroyuki Amano1

  • 1Department of Respiratory Medicine, Funabashi Municipal Medical Center, Japan.

Internal Medicine (Tokyo, Japan)
|October 13, 2017
PubMed
Summary

An 86-year-old lung adenocarcinoma patient experienced an abdominal abscess during crizotinib treatment. This rare complication, linked to lower intestinal tract perforation, resolved after treatment adjustment to alectinib.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Stage IV lung adenocarcinoma requires targeted therapy, often involving anaplastic lymphoma kinase (ALK) inhibitors.
Keywords:
ALK rearrangementalectinibcrizotinibintestinal tract perforationnon-small cell lung cancer

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  • Echinoderm microtubule-associated protein-like 4 (EML4)-ALK rearrangements are a key target in lung cancer treatment.
  • Crizotinib is a first-generation ALK inhibitor used for advanced lung adenocarcinoma.