Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Clinical implications of serum total VEGF-A and VEGF-A isoforms in patients with EGFR-mutated advanced non-small cell lung cancer treated with EGFR-TKIs.

International journal of clinical oncology·2026

Same author

Diversity of Factors Associated with Physical Inactivity in Patients with Asthma Based on Activity Intensity.

Journal of clinical medicine·2026

Same author

Clinical implications of serum total VEGF-A and VEGF-A isoforms in patients with EGFR-mutated advanced non-small cell lung cancer treated with EGFR-TKIs.

International journal of clinical oncology·2026

Same author

Baseline Neutrophil-To-Lymphocyte Ratio as a Risk Stratification Marker for Severe Checkpoint Inhibitor Pneumonitis in Patients With Non-Small Cell Lung Cancer: A Two-Cohort Study With Retrospective Discovery and Prospective Validation.

Respirology (Carlton, Vic.)·2026

Same author

COPD prescription patterns after the 2018 Japan floods: analysis of national data.

Scientific reports·2026

Same author

Clinical utility of the bronchial washing-to-serum galactomannan antigen ratio for the diagnosis of pulmonary aspergillosis.

Journal of microbiological methods·2026

Search research articles

Related Experiment Video

Updated: Feb 21, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated

Masashi Namba¹, Takeshi Masuda¹, Takashi Nakamura²

¹Department of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.

Internal Medicine (Tokyo, Japan)

|October 13, 2017

Summary

Sirolimus can treat chylous effusion in lymphangioleiomyomatosis (LAM). However, one patient developed refractory chylous effusion during sirolimus therapy, which improved with the addition of octreotide.

Keywords:

chylothorax chylous ascites lymphangioleiomyomatosis octreotide sirolimus

More Related Videos

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Related Experiment Videos

Last Updated: Feb 21, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Area of Science:

Medical research
Pulmonology
Oncology

Background:

Lymphangioleiomyomatosis (LAM) is a rare lung disease.
Chylous effusion is a common complication of LAM.
Sirolimus (an mTOR inhibitor) has shown promise in managing chylous effusion in LAM patients.

Observation:

A 34-year-old woman with LAM experienced refractory chylothorax and chylous ascites despite sirolimus treatment.
Octreotide, typically used for postoperative chylous effusion, was administered alongside sirolimus.

Findings:

The combination of sirolimus and octreotide effectively reduced both chylothorax and chylous ascites in this LAM patient.
This suggests a potential synergistic effect in managing refractory chylous effusions.

Implications:

Octreotide may be a valuable addition to sirolimus therapy for LAM patients with refractory chylous effusions.
This case highlights a potential therapeutic strategy for difficult-to-treat LAM complications.
Further research is warranted to confirm the efficacy and safety of this combination therapy.