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Updated: Feb 21, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Structure of the Microemulsion of Polyglycerol Polyricinoleate Encapsulating Vitamin E
Junji Matsuoka1, Takumi Kusano1, Yuuki Kasama2
1Institute for Solid State Physics, The University of Tokyo.
Abstract:
The structures of micelles and microemulsions consisting of polyglycerol polyricinoleate (PGPR) were investigated by small-angle X-ray scattering (SAXS) and rheological measurements. The SAXS results show that amphiphilic PGPR molecules form stable micelles in glycerol. When vitamin E is added to the PGPR micelles, it is encapsulated in the micelles and forms an emulsion. These micelles are stable towards mechanical shearing up to a shear rate of 1000 s-1, with shear thinning occurring in the emulsion above 100 s-1, indicating that the emulsion may undergo break up by shearing, but recovers the structure by releasing shear strain.
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