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Related Experiment Videos

LY141865: a relatively selective DA2 agonist with complex ocular activity.

D E Potter1, J A Burke

  • 1Center for Biotechnology, Baylor College of Medicine, Woodlands, Texas.

Journal of Ocular Pharmacology
|January 1, 1988
PubMed
Summary

LY141865, an ergoline derivative, effectively lowers intraocular pressure in animal models. Its ocular hypotensive effects suggest potential central nervous system involvement, warranting further investigation for glaucoma treatment.

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Neuroscience

Background:

  • Ergoline derivatives are known for various pharmacological activities.
  • Intraocular pressure (IOP) regulation is crucial for ocular health.
  • Understanding the mechanisms of ocular hypotensive agents is important for treating glaucoma.

Purpose of the Study:

  • To investigate the ocular effects of LY141865 (LY), an ergoline derivative.
  • To determine if LY affects intraocular pressure (IOP) in animal models.
  • To explore the potential central nervous system (CNS) mediation of LY's ocular effects.

Main Methods:

  • LY141865 was administered to rabbits and monkeys to assess ocular effects.
  • Intraocular pressure (IOP) was measured bilaterally in both species.

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  • Experiments included oral waterloading challenges and interventions like sympathectomy and sulpiride pretreatment in rabbits.

    • Main Results:

    • LY141865 significantly lowered intraocular pressure (IOP) bilaterally in monkeys and rabbits.
    • LY141865 prevented IOP elevation induced by oral waterloading in rabbits.
    • LY141865 slowed the rate of IOP recovery in rabbits.
    • The ocular hypotensive activity of LY in rabbits was diminished by sympathectomy and sulpiride.

    Conclusions:

    • LY141865 exhibits significant ocular hypotensive activity in rabbits and monkeys.
    • The findings suggest that the ocular effects of LY may be partly mediated by the central nervous system (CNS).
    • Further research into the CNS mechanisms of LY is warranted for potential therapeutic applications in managing ocular pressure.