Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs

H₂S is a gaseous molecule able to trigger a plethora of central physiological and pharmacological effects as antioxidant, pro- and anti-inflammatory, pro- and anti-nociceptive, neuromodulator, and cytoprotective. The polypharmacology of H₂S depends on the wide variety of targets implicated, but, despite the efforts, the mechanisms of action that should clarify its activity are still not completely unrevealed. Nevertheless, many attempts to exploit the multifaceted profile of this molecule have already been accomplished and many chemical entities containing an H₂S-releasing pharmacophore have been synthetized. Here we discuss recent investigations on multitarget molecules able to release H₂S, with a particular focus on the combinations of "native drug" with moieties structurally able to release H₂S and their applications as therapeutic tools in bone disease, gastrointestinal system and neurodegenerative disorders.