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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.0K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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What is the Immune System?01:38

What is the Immune System?

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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
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Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

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Autoimmune enteropathies.

Sarah E Umetsu1, Ian Brown2, Cord Langner3

  • 1Department of Pathology, University of California, San Francisco, 505 Parnassus Avenue, Room M551A, Box 0102, San Francisco, CA, 94143-0102, USA. sarah.umetsu@ucsf.edu.

Virchows Archiv : an International Journal of Pathology
|October 13, 2017
PubMed
Summary
This summary is machine-generated.

Autoimmune enteropathy (AIE) is a rare, challenging diagnosis due to variable symptoms and histopathology. Recognizing diverse clinical and histologic patterns is key for accurate diagnosis and understanding intestinal immune dysregulation.

Keywords:
Autoimmune diseaseColitisDrug inducedEnteritisImmunodeficiencyInherited disease

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Autoimmune enteropathy (AIE) is a rare condition causing severe diarrhea and intestinal mucosal damage.
  • Diagnosis is difficult due to highly variable clinical and histopathologic features.
  • AIE is linked to immune dysregulation and often presents with immunodeficiency, especially in children.

Purpose of the Study:

  • To highlight the diagnostic challenges of autoimmune enteropathy.
  • To emphasize the variability in clinical and histopathologic manifestations.
  • To underscore the importance of recognizing diverse patterns for diagnosis.

Main Methods:

  • Review of clinical and histopathologic findings in autoimmune enteropathy.
  • Analysis of the heterogeneity of disorders associated with AIE.
  • Discussion of the role of intestinal immunity and immunodeficiency.

Main Results:

  • Autoimmune enteropathy presents with a wide spectrum of clinical and histopathologic features.
  • The term "autoimmune enteropathies" reflects the association with various disorders.
  • Common histopathologic changes include mucosal inflammation and epithelial injury with diverse patterns.

Conclusions:

  • Accurate diagnosis of AIE requires careful consideration of clinical context and histologic patterns.
  • Understanding the variable presentation is crucial for effective patient management.
  • Further research into AIE pathophysiology is needed to elucidate the role of intestinal immunity.