Physical Exercise Is a Potential "Medicine" for Atherosclerosis

Area of Science:

• Cardiovascular Medicine
• Exercise Physiology
• Pathology

Background:

• Cardiovascular disease (CVD) remains a leading cause of mortality globally.
• Atherosclerosis, a primary risk factor for CVD, is a chronic, progressive inflammatory condition.
• This process involves complex interactions of oxidative stress, macrophages, and inflammatory factors.

Purpose of the Study:

• To summarize the mechanisms underlying the beneficial effects of physical exercise on atherosclerosis.
• To explore the potential clinical applications of exercise as a therapeutic intervention for atherosclerosis.
• To highlight the dose-dependent nature of exercise's therapeutic effects.

Main Methods:

• Literature review of recent studies on physical exercise and atherosclerosis.
• Analysis of the molecular and cellular mechanisms involved in exercise's impact on atherosclerotic processes.
• Synthesis of evidence regarding the clinical efficacy and safety of exercise interventions.

Main Results:

• Physical exercise demonstrates therapeutic potential in managing atherosclerosis.
• The beneficial effects of exercise are contingent upon the dosage and intensity.
• Inappropriate or excessive exercise may lead to adverse cardiac outcomes.

Conclusions:

• Physical exercise can be a valuable therapeutic strategy for atherosclerosis.
• Understanding the dose-response relationship is crucial for optimizing exercise prescriptions.
• Further research is warranted to establish precise exercise guidelines for clinical use in managing atherosclerosis and preventing CVD.