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Ketogenic diet in endocrine disorders: Current perspectives.

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The ketogenic diet (KD), a low-carbohydrate eating plan, shows promise for managing diabetes, obesity, and endocrine disorders. It offers benefits like improved glycemic control and weight loss, with a vegetarian variant available.

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Area of Science:

  • Nutrition and Metabolism
  • Endocrinology
  • Dietary Science

Background:

  • The ketogenic diet (KD) is characterized by high fat, adequate protein, and low carbohydrate intake, inducing nutritional ketosis.
  • Historically recognized for its antiepileptic effects, KD has therapeutic applications in refractory epilepsy.

Purpose of the Study:

  • To review the evidence and clinical applications of the ketogenic diet in diabetes, obesity, and other endocrine disorders.
  • To present a vegetarian Indian variant of the KD tailored to local dietary habits.

Main Methods:

  • Literature review summarizing existing evidence on KD.
  • Description of a vegetarian Indian variant of the KD.

Main Results:

  • KD demonstrates beneficial effects on cardiac ischemic preconditioning and improves oxygenation in respiratory failure.
  • Significant improvements in glycemic control in diabetics and notable weight loss are associated with KD.
  • Positive impacts on polycystic ovarian syndrome (PCOS) have been observed.

Conclusions:

  • The ketogenic diet is a promising therapeutic option for diabetes, obesity, and endocrine disorders, including PCOS.
  • Ketones are increasingly recognized as a potent metabolic fuel, positioning KD as a suitable therapy for "diabesity."
  • Multivitamin supplementation is recommended when following a KD.